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Readings for this course consist of the textbook, optional papers, and some suggested supplemental sources.
Textbook readings listed are in the course textbook:
Golan, D., et. al., eds. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Philadelphia, PA: Lippincott Williams and Wilkins, 2004. ISBN: 9780781746786.
The emphasis, particularly in long assignments like antibiotics, should be on mechanisms of action and principles of therapy rather than minutiae about individual drugs.
Course readings.
| LEC # |
TOPICS |
TEXTBOOK READINGS |
optional PAPERS |
| 1 |
Introduction
Receptors / Dose-Response |
pp. 3-26 |
|
| 2 |
Pharmacokinetics I
Pharmacokinetics II |
pp. 27-43 |
|
| 3 |
Interpreting Clinical Literature
Cholinergic Pharmacology
Case: Anticholinesterase |
pp. 55-106, and 724-725 |
Bernard, G. R., et. al. "Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis." The New England Journal of Medicine 344, no. 10 (2001): 699-709. |
| 4 |
Drug Metabolism
Pharmacogenetics
Cases: Anticoagulation, Sulfasalazine |
pp. 45-54, 803-809, and 350-353 |
|
| 5 |
Autonomic Pharmacology I
Autonomic Pharmacology II
Cases: Pheochromocytoma, Asthma |
pp. 205-228, 71-86, 107-120, and 695-708 |
|
| 6 |
Local Anesthetics
Antidysrhythmics
Cases: Poison Control, Cocaine |
pp. 205-228, 121-136, 267-284, and 719-743 |
Buxton, Alfred E., et. al. "A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease." The New England Journal of Medicine 341, no. 25 (1999): 1882-1890. |
| 7 |
Pharmacokinetics III
Antiinflammatory Drugs
Case: Glaucoma |
pp. 781-787, and 617-646 |
Weinblatt, Michael E., et. al. "A Trial of Etanercept, a Recombinant Tumor Necrosis Factor Receptor: Fc Fusion Protein, in Patients with Rheumatoid Arthritis Receiving Methotrexate." The New England Journal of Medicine 340, no. 4 (1999): 253-259.
Edwards, David A., et. al. "Large Porous Particles for Pulmonary Drug Delivery." Science 276, no. 5320 (1997): 1868-1871.
Langer, Robert J. "New Methods of Drug Delivery." Science 249, no. 4976 (1990): 1527-1533. |
| 8 |
Vasoactive Drugs I
Vasoactive Drugs II: Heart Failure
Cases: Pharmacogenetics, Thyroid Disease |
pp. 285-333, 375-399, and 415-424 |
Wing, Lindon M. H., et. al. "A Comparison of Outcomes with Angiotensin-converting-enzyme Inhibitors and Diuretics for Hypertension in the Elderly." The New England Journal of Medicine 348, no. 7 (2003): 583-592.
The Digitalis Investigation Group. "The Effect of Digoxin on Mortality and Morbidity in Patients with Heart Failure." The New England Journal of Medicine 336, no. 8 (1997): 525-533. |
| 9 |
Lipid Lowering Drugs
Cases: Placental Transfer, Gout |
pp. 357-374, 447, and 709-715 |
Knopp, Robert H. "Drug Treatment of Lipid Disorders." The New England Journal of Medicine 341, no. 7 (1999): 498-511. |
| 10 |
Antihistamines
Immunosuppression for Solid Organ Transplantation
Cases: Antiemetics, Geriatric Pharmacology |
pp. 647-654, 683-694, and 667-681 |
Simons, F. Estelle R. "Advances in H1-Antihistamines." The New England Journal of Medicine 351, no. 21 (2004): 2203-2217. |
| 11 |
Drug Development |
pp. 747-756, and 791-801 |
Lazo, John S., and Peter Wipf. "Combinatorial Chemistry and Contemporary Pharmacology." The Journal of Pharmacology and Experimental Therapeutics 298, no. 8 (2000): 705-709. |
| 12 |
Neuropharmacology I: Drugs for Movement Disorders
Nitric Oxide
Cases: Placebo, Renal Failure |
pp. 161-178, and 40 |
Ichinose, Fumito, Jesse D. Roberts, Jr., and Warren M. Zapol. "Inhaled Nitric Oxide: A Selective Pulmonary Vasodilator: Current Uses and Therapeutic Potential." Circulation 109, no. 25 (2004): 3106-3111.
Steudel, Wolfgang, William E. Hurford, and Warren M. Zapol. "Inhaled Nitric Oxide: Basic Biology and Clinical Applications." Anesthesiology 91, no. 4 (1990): 1090-1121. |
| 13 |
Neuropharmacology II: Anxiolytics and Antidepressants
Neuropharmacology III: Anticonvulsants
Cases: Lithium, Alcohol |
pp. 139-159, 179-204, and 260-261 |
|
| 14 |
Antimicrobials I
Antimicrobials II
Cases: Drug Allergy, Migraines |
pp. 493-504, 535-544, 565-578, and 603-613 |
Rodvold, Keith A. "Pharmacodynamics of Antiinfective Therapy: Taking What We Know to the Patient's Bedside." Pharmacotherapy 21, no. 11, Pt 2 (2001): 319S - 330S. |
| 15 |
Chemotherapy I
Chemotherapy II
Cases: Folate, Oral Hypoglycemics |
pp. 505-554, and 457-471 |
|
| 16 |
Opioids I
Opioids II
Cases: Cancer - Analgesia, Drug Abuse |
pp. 229-263 |
Kieffer, B. L. "Opioids: First Lessons from Knockout Mice." Trends in Pharmacological Sciences 20, no. 1 (1999): 19-26. |
Some topics will reference additional sources, including:
Hardman, J. G., et. al., eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001. ISBN: 9780071354691.
Katzung, B., et. al., eds. Basic and Clinical Pharmacology. 9th ed. New York, NY: McGraw-Hill, 2003. ISBN: 9780071410922.
Katzung may be particularly helpful on the following topics:
- Sulfasalazine and ulcerative colitis
- Pheochromocytoma
- Glaucoma
- Teratogenesis and placental transfer
- Antiemetics
- Geriatric pharmacology
- Placebo
- Drug allergy
- Migraines